Quinolines and derivatives
Apexbio Technology LLC Nicotinamide Riboside Chloride (NIAGEN)(Synonyms: NR Chloride, Niagen, Nicotinamide Riboside Chloride, NR-Cl, Nicotinamide Riboside Cl), 200mg, CAS: 23111-00-4.
Nicotinamide Riboside Chloride (NIAGEN CAS 23111-00-4) is a small molecule precursor of nicotinamide adenine dinucleotide (NAD ) an essential cofactor implicated in energy metabolism and cellular homeostasis Upon oral administration it effectively elevates intracellular NAD levels subsequently modulating the activity of NAD -dependent sirtuin enzymes particularly SIRT1 and SIRT3 Experimental evidence indicates that Nicotinamide Riboside Chloride enhances oxidative metabolism and mitigates metabolic dysfunction induced by high-fat dietary conditions Additionally studies employing Alzheimer s disease transgenic mouse models suggest that this compound can reduce cognitive decline supporting its use in biomedical research targeting metabolic and neurodegenerative conditions
Medchemexpress LLC Branaplam | 1562338-42-4 | 98.90% | 393.48 | 200 MG
Branaplam is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. It inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.
- Highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator.
- Elevates full-length SMN protein.
- Extends survival in a severe spinal muscular atrophy (SMA) mouse model.
- EC50 of 20 nM for SMN.
- IC50 of 6.3 μM for hERG.
Apexbio Technology LLC Regorafenib hydrochloride(Synonyms: Regorafenib HCl, BAY 73-4506, Stivarga, BAY73-4506 hydrochloride, Regorafenib hydrochloride salt), 200mg, CAS: 835621-07-3.
Regorafenib hydrochloride (CAS 835621-07-3) is an orally bioavailable small molecule inhibitor targeting multiple protein kinases including c-KIT VEGFR2 and B-Raf It inhibits these kinases with IC50 values of approximately 17 nM (c-KIT) 40 nM (VEGFR2) and 69 nM (B-Raf) By blocking kinase signaling Regorafenib hydrochloride effectively interrupts tumor-associated pathways involved in cell proliferation angiogenesis and survival It is widely used in oncology research for studies focused on kinase-mediated tumor growth and vascularization mechanisms
eMolecules 57334-35-7 | 5-METHOXY-8-QUINOLINOL | MFCD18414704 | 1g
AstaTech | 5-METHOXY-8-QUINOLINOL | 1g | 273172844 | 76306 | 95.000 | 57334-35-7 | MFCD18414704 | 175.187 | C10H9NO2
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Medchemexpress LLC Vk-II-86 (carvedilol analogue) | 955371-84-3 | 93.3% | 420.50 | C25H28N2O4 | 5 MG
VK-II-86 is a carvedilol analogue and a store-overload-induced calcium release (SOICR) inhibitor used as a research chemical to study cardiac arrhythmia mechanisms and calcium homeostasis. It lacks β-adrenoceptor antagonist activity and has been shown to prevent hypokalaemia-induced ventricular arrhythmia by normalizing ion channel activity and repolarization reserve.
- Inhibits store-overload-induced calcium release, supporting arrhythmia research.
- Lacks β-adrenoceptor antagonist activity, reducing β-blocking confounds in studies.
- Reported to normalize calcium homeostasis and repolarization reserve in models.
- Solid, light brown to brown appearance and supplied in small milligram quantities.
- Molecular weight 420.50 g/mol; formula C25H28N2O4.
- High purity (93.3%) suitable for laboratory research applications.
Apexbio Technology LLC Sodium Phenylbutyrate 1716-12-7 200mg
Sodium Phenylbutyrate (CAS 1716-12-7) is a small-molecule inhibitor targeting histone deacetylase (HDAC) an enzyme involved in regulating histone acetylation an epigenetic mechanism implicated in cancer progression and cardiac dysfunction In oral squamous cell carcinoma cell lines (CAL27 HSC3 SCC4) Sodium Phenylbutyrate demonstrated dose-dependent cell growth inhibition (IC50 4 091 3 712 and 3 015 mM respectively) and decreased cell viability in a time-dependent manner In a mouse Adriamycin-induced cardiac injury model treatment with Sodium Phenylbutyrate significantly attenuated cardiac enzyme elevations improved cardiac function and increased cardiac MnSOD protein expression and activity Sodium Phenylbutyrate serves as an important research tool for cancer biology and cardiotoxicity studies
Medchemexpress LLC Navitoclax (ABT-263) | 923564-51-6 | MFCD12756219 | ≥98.0% | 974.61 g·mol⁻¹ | C47H55ClF3N5O6S3 | 200 MG
Navitoclax (ABT-263) is a potent, orally active small-molecule inhibitor of anti-apoptotic Bcl-2 family proteins used in preclinical apoptosis and oncology research. Supplied as a powder, it is used for both in vitro assays and in vivo models, with documented solubility and recommended storage for stability.
- Potent Bcl-2 family inhibitor for apoptosis research.
- Orally active small molecule suitable for in vivo studies.
- High solubility in DMSO for convenient stock solutions.
- Available in multiple quantities for dosing flexibility.
- Recommended storage conditions to preserve stability.
Apexbio Technology LLC WAY-100635 162760-96-5 200mg
WAY-100635 (CAS 162760-96-5) is a highly selective antagonist of the serotonin 5-HT1A receptor In vitro studies show that WAY-100635 displaces the 5-HT1A radioligand [3H]8-OH-DPAT from rat hippocampal membranes with a pIC50 of 8 87 and acts as a potent antagonist in functional assays without agonist or partial agonist activity In ex vivo guinea pig ileum assays it effectively blocks 5-carboxamidotryptamine-induced 5-HT1A responses (pA2 9 71 at 0 3 nM) In vivo WAY-100635 counteracts 8-OH-DPAT-induced behavioral and thermoregulatory effects in rodents at subcutaneous doses as low as 0 003 0 01 mg/kg It is widely utilized in neuropharmacological research and neuroimaging as a SPECT/PET ligand to investigate 5-HT1A receptor function in psychiatric and neurological disorders
Medchemexpress LLC Kaempferol | 520-18-3 | MFCD00004543 | 99.9% | C15H10O6 | 200 MG
Kaempferol is a naturally occurring flavonoid found in various edible plants. This compound functions as an estrogen receptor alpha inhibitor in breast cancer cells and promotes apoptosis in glioblastoma and lung cancer cells through MEK-MAPK activation. It is recognized as a human endogenous metabolite.
- Inhibits estrogen receptor alpha expression in breast cancer cells.
- Induces apoptosis in glioblastoma and lung cancer cells.
- Demonstrates anti-inflammatory activity.
- Exhibits antioxidant activity in human HepG2 cells.
- Shows antiproliferative activity against certain human cancer cell lines.
- Displays antiallergic activity.
- Demonstrates antiviral activity against influenza A virus.
- Inhibits melanogenesis.
- Inhibits procoagulant activity.
- Induces osteoclast apoptosis.
- Exhibits antiaggregatory activity in human platelets.
Medchemexpress LLC (S)-Rasagiline | 185517-74-2 | >98% | C12H13N | 200 MG
(S)-Rasagiline (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. It is a highly potent, selective, irreversible MAO inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively. It also functions as a click chemistry reagent.
- Relatively inactive S-enantiomer form of rasagiline
- Highly potent, selective, irreversible MAO inhibitor
- IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity
- Functions as a click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups
Apexbio Technology LLC LY2784544 1229236-86-5 200mg
LY2784544 (CAS 1229236-86-5) is a potent and selective ATP-competitive inhibitor of JAK2 tyrosine kinase exhibiting an IC50 of 3 nM It demonstrates 8-fold and 16-fold selectivity over JAK1 and JAK3 respectively In cellular assays LY2784544 effectively inhibits STAT5 phosphorylation in Ba/F3-TEL-JAK2 cells (IC50 0 191 nM) while displaying substantially reduced activity against JAK1 and JAK3-dependent STAT5 phosphorylation The compound suppresses proliferation and induces apoptosis in cells harboring the JAK2 V617F mutation In murine models it reduces tumor burden and strongly inhibits STAT5 phosphorylation in JAK2 V617F-driven cells LY2784544 is a valuable tool for studying JAK2-mediated signaling and myeloproliferative neoplasms
TARGETMOL CHEMICALS INC ALACEPRIL 50MG
Also available in 10 mg 25 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Alacepril (DU-1219) is a relatively novel angiotensin-converting enzyme inhibitor used as an antihypertensivepurity: 98%
Apexbio Technology LLC Wnt agonist 1(Synonyms: Wnt Agonist I, Wnt signaling activator I, Wnt agonist compound 1, Wnt agonist-I), 200mg, CAS: 853220-52-7.
Wnt agonist 1 (CAS 853220-52-7) is a small-molecule stimulator of the canonical Wnt signaling pathway It functions by activating -catenin-dependent transcription mediated through the TCF transcription factor with an EC50 of approximately 0 7 M In Xenopus embryos treated from developmental stage 10 5 to stage 40 with Wnt agonist 1 (10 M) notable cephalic defects including reduced head size or absent eyes were observed mirroring phenotypes associated with increased Wnt signaling Researchers use Wnt agonist 1 to investigate Wnt pathway-regulated cellular differentiation and development
Medchemexpress LLC Cilazapril monohydrate | 92077-78-6 | 99.9% | C22H33N3O6 | 50 MG
Cilazapril monohydrate is an orally active prodrug of an angiotensin-converting enzyme (ACE) inhibitor. It functions by reducing plasma ACE activity and is utilized in research concerning hypertension, including essential and renal hypertension, and congestive heart failure.
- Used in research of hypertension (including essential and renal hypertension) and congestive heart failure.
- Evokes maximum degree of plasma ACE inhibition in rats.
- Dose-dependently reduces plasma ACE activity and pressor response to angiotensin in cats.
- Gradually reduces blood pressure in dogs with volume-depleted renal hypertension.
- Decreases blood pressure, reduces heart weight to body weight ratio, and improves postischemic myocardial function in hyperthyroid rats.